Surgical management of a metastatic vertebral tumour originating from a mammary adenocarcinoma in a dog

Nam A, Hong SH, Jee HC, Lee WJ, Myung H, Kim DH (2022): Surgical management of a metastatic vertebral tumour originating from a mammary adenocarcinoma in a dog. Vet Med-Czech 67, 644–650.

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An 11-year-old spayed female Toy Poodle presented with acute tetraparesis. A small subcutaneous mass was found in the right trunk region, and the magnetic resonance revealed a compressive spinal cord lesion due to an irregular bone proliferation at the third cervical vertebra. After surgical resection of the vertebral lesion, the neurological symptoms improved, and the patient could walk on her own. The excised vertebral and subcutaneous masses were diagnosed as a mammary adenocarcinoma on the histopathological examination, with Ki-67 and HER-2 immunohistochemistry staining. This case report highlights the importance of defining the primary tumours of metastatic vertebral tumours and the necessity of palliative surgery to improve the patient’s quality of life.

Asano K, Kadosawa T, Mori T, Miyamoto T, Ueno H, Watanabe K, Fujinaga T. Ventilatory failure and successful management for a dog with severe cervical meningioma. J Vet Med Sci. 2005 Jun;67(6):599-602.
Bagley RS. Spinal neoplasms in small animals. Vet Clin North Am Small Anim Pract. 2010 Sep;40(5):915-27.
Besalti O, Caliskan M, Can P, Vural SA, Algin O, Ahlat O. Imaging and surgical outcomes of spinal tumors in 18 dogs and one cat. J Vet Sci. 2016 Jun 30;17(2):225-34.
Chun R, de Lorimier LP. Update on the biology and management of canine osteosarcoma. Vet Clin North Am Small Anim Pract. 2003 May;33(3):491-516.
Cooley DM, Waters DJ. Skeletal metastasis as the initial clinical manifestation of metastatic carcinoma in 19 dogs. J Vet Intern Med. 1998 Jul-Aug;12(4):288-93.
Dorn CR, Taylor DO, Schneider R, Hibbard HH, Klauber MR. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968 Feb;40(2):307-18.
Egenvall A, Nodtvedt A, von Euler H. Bone tumors in a population of 400 000 insured Swedish dogs up to 10 y of age: Incidence and survival. Can J Vet Res. 2007;71(4):292-9.
Goedegebuure SA. Secondary bone tumours in the dog. Vet Pathol. 1979 Sep;16(5):520-9.
Gruntzig K, Graf R, Hassig M, Welle M, Meier D, Lott G, Erni D, Schenker NS, Guscetti F, Boo G, Axhausen K, Fabrikant S, Folkers G, Pospischil A. The Swiss Canine Cancer Registry: A retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol. 2015 Feb-Apr;152(2-3):161-71.
Milch RA. Surgical palliative care. Semin Oncol. 2005 Apr;32(2):165-8.
Misdorp W, Cotchin E, Hampe JF, Jabara AG, von Sandersleben J. Canine malignant mammary tumours. II. Adenocarcinomas, solid carcinomas and spindle cell carcinomas. Vet Pathol. 1972 Nov;9(6):447-70.
North SM, Banks TA. Tumors of the nervous system. In: North SM, Banks TA, editors. Small animal oncology. An introduction. Edinburgh, UK: Saunders; 2009. p. 243-52.
Pancotto TE, Rossmeisl JH Jr, Zimmerman K, Robertson JL, Werre SR. Intramedullary spinal cord neoplasia in 53 dogs (1990–2010): Distribution, clinicopathologic characteristics, and clinical behavior. J Vet Intern Med. 2013 Nov-Dec;27(6):1500-8.
Pastor N, Caballe NC, Santella M, Ezquerra LJ, Tarazona R, Duran E. Epidemiological study of canine mammary tumors: Age, breed, size and malignancy. Austral J Vet Sci. 2018 Jan;50(3):143-7.
Salas Y, Marquez A, Diaz D, Romero L. Epidemiological study of mammary tumors in female dogs diagnosed during the period 2002–2012: A growing animal health problem. PLoS One. 2015 May 18;10(5):e0127381.
Seguin B, Bagley RS, Silver G. Diagnosis and treatment of spinal neoplasia in dogs and cats. Waltham Focus. 2000;10(3):4-9.
Sorenmo K. Canine mammary gland tumors. Vet Clin North Am Small Anim Pract. 2003 May;33(3):573-96.
Sorenmo KU, Kristiansen VM, Cofone MA, Shofer FS, Breen AM, Langeland M, Mongil CM, Grondahl AM, Teige J, Goldschmidt MH. Canine mammary gland tumours; A histological continuum from benign to malignant; Clinical and histopathological evidence. Vet Comp Oncol. 2009 Sep;7(3):162-72.
Thompson KG, Dittmer KE. Tumors of bones. In: Meuten DJ, editor. Tumors in domestic animals. 5th ed. North Carolina, USA: Wiley Blackwell; 2017. p. 356-424.
Trost ME, Inkelmann MA, Galiza GJ, Silva TM, Kommers GD. Occurrence of tumours metastatic to bones and multicentric tumours with skeletal involvement in dogs. J Comp Pathol. 2014 Jan;150(1):8-17.
Valentim LG, Marcasso RA, Bracarense AP, Arias MV. Spinal neoplasm in dogs. Acta Sci Vet. 2016 Jul-Dec;44(1): [10].
Vanel M, Blond L, Vanel D. Imaging of primary bone tumors in veterinary medicine: Which differences? Eur J Radiol. 2013 Dec;82(12):2129-39.
Vascellari M, Capello K, Carminato A, Zanardello C, Baioni E, Mutinelli F. Incidence of mammary tumors in the canine population living in the Veneto region (Northeastern Italy): Risk factors and similarities to human breast cancer. Prev Vet Med. 2016 Apr 1;126:183-9.
Zuchi TLVL, Lopatini CL, Spricigo JB, Sueiro FAR, Faria JLM. A rare bone metastasis of mammary carcinoma in a female dog: Case report. Acta Vet Bras. 2020 Dec;14(4):226-30.
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